Application of 53312-81-5, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 53312-81-5, Name is 5-Amino-2-fluorobenzonitrile, SMILES is NC1=CC(=C(C=C1)F)C#N, belongs to nitriles-buliding-blocks compound. In a article, author is Kowalczyk, Anna, introduce new discover of the category.
A straightforward access to 3-trifluoromethyl-1H-indazoles via (3+2)-cycloaddition of arynes with nitrile imines derived from trifluoroacetonitrile
In situ generated arynes react with nitrile imines derived from trifluoroacetonitrile at 0 degrees C in THE solutions yielding 3-trifluoromethyl-1H-indazole derivatives as the only intermolecular products. The reaction corresponds the expected (3 + 2)-cycloadditions which belong to the Type III (inverse-electron-demand) of Sustmann’s classification. Subsequent CAN-mediated dearylation of the model N-(p-methoxy)phenyl indazole leads to N-unsubstituted analogue, which easily undergoes alkylation and acylation reactions. Presented protocol offers a superior method for preparation of the 3-CF3 substituted indazole derivatives.
Application of 53312-81-5, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 53312-81-5 is helpful to your research.