Application of 619-72-7, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 619-72-7, Name is 4-Nitrobenzonitrile, SMILES is C1=CC(=CC=C1[N+](=O)[O-])C#N, belongs to nitriles-buliding-blocks compound. In a article, author is Balaji, Pandur Venkatesan, introduce new discover of the category.
Direct Catalytic Asymmetric Addition of alpha-Fluoronitriles to Aldehydes
A fluorine-containing tetrasubstituted stereogenic center is a highly valued structural feature in medicinal chemistry. Herein, we describe the direct coupling of racemic alpha-fluoronitriles and aldehydes promoted by a chiral Cu-I/Barton’s base catalytic system, delivering alpha-tetrasubstituted alpha-fluoro-beta-hydroxynitriles with satisfactory stereoselection. The stereochemical course was positively biased by the combined use of asymmetrical achiral thiourea as a supplementary ligand for Cu-I, which significantly enhanced the stereoselectivity. Both aromatic and aliphatic aldehydes were implemented to provide densely and stereoselectively functionalized chiral building blocks with aliphatic and aromatic tails.
Application of 619-72-7, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 619-72-7 is helpful to your research.