In an article, author is Utecht-Jarzynska, Greta, once mentioned the application of 1897-52-5, Product Details of 1897-52-5, Name is 2,6-Difluorobenzonitrile, molecular formula is C7H3F2N, molecular weight is 139.1, MDL number is MFCD00001778, category is nitriles-buliding-blocks. Now introduce a scientific discovery about this category.
Highly fluorinated 2,3-dihydro-1,3,4-thiadiazole derivatives via [3+2]-cycloadditions of tertiary thioamides with nitrile imines derived from trifluoroacetonitrile
Fluorine-rich 1,3,4-thiadiazole derivatives were prepared by 1,3-dipolar cycloaddition of the in situ generated N-aryl-trifluoroacetonitrile imines with tertiary polyfluoroalkanethioamides (N,N-dialkyl thioamides). Reactions were performed under mild conditions in THE solutions at room temperature. The 1,3,4-thiadiazole derivatives were formed in a fully regioselective manner in high yields. In a competition experiment, the non-fluorinated 1-(morpholin-4-yl)ethanethione was shown to be more reactive towards a model nitrile imine than its 2,2,2-trifluommethylated analogue.
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