Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Quality Control of 2-Bromoacetonitrile590-17-0, Name is 2-Bromoacetonitrile, SMILES is N#CCBr, belongs to nitriles-buliding-blocks compound. In a article, author is Zhang, Xiao-Wei, introduce new discover of the category.
Oxidize Amines to Nitrile Oxides: One Type of Amine Oxidation and Its Application to Directly Construct Isoxazoles and Isoxazolines
A facile oxidative heterocyclization of commercially available amines and tert-butyl nitrite with alkynes or alkenes leading to isoxazoles or isoxazolines is described. The unprecedented strategy of the oxidation of an amine directly to a nitrile oxide was used in this cyclization process. This reaction is highly efficient, regiospecific, operationally simple, mild, and tolerant of a variety of functional groups. Control experiments support a nitrile oxide intermediate mechanism for this novel class of oxidative cyclization reactions. Moreover, synthetic applications toward bioactive molecular skeletons and the late-stage modification of drugs were realized.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 590-17-0. Quality Control of 2-Bromoacetonitrile.