In an article, author is Ruan, Shixiang, once mentioned the application of 619-72-7, Name is 4-Nitrobenzonitrile, molecular formula is C7H4N2O2, molecular weight is 148.12, MDL number is MFCD00007279, category is nitriles-buliding-blocks. Now introduce a scientific discovery about this category, Application In Synthesis of 4-Nitrobenzonitrile.
Facile dehydration of primary amides to nitriles catalyzed by lead salts: The anionic ligand matters
The synthesis of nitrile under mild conditions was achieved via dehydration of primary amide using lead salts as catalyst. The reaction processes were intensified by not only adding surfactant but also continuously removing the only by-product, water from the system. Both aliphatic and aromatic nitriles can be prepared in this manner with moderate to excellent yields. The reaction mechanisms were obtained with high-level quantum chemical calculations, and the crucial role the anionic ligand plays in the transformations were revealed.
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