Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Name: 2-Amino-4-chlorobenzonitrile, 38487-86-4, Name is 2-Amino-4-chlorobenzonitrile, SMILES is NC1=CC(Cl)=CC=C1C#N, belongs to nitriles-buliding-blocks compound. In a document, author is Astakhov, Grigorii S., introduce the new discover.
Facile synthesis of pyrrolo[2,1-a]isoquinolines by domino reaction of 1-aroyl-3,4-dihydroisoquinolines with conjugated ketones, nitroalkenes and nitriles
A convenient protocol for the synthesis of 5,6-dihydropyrrolo[2,1-a]isoquinolines with various electron-withdrawing substituents at C-2 atom is described. This approach is based on the two-component domino reaction of 1-aroyl-3,4-dihydroisoquinolines with alpha,beta-unsaturated ketones, nitroalkenes and acrylonitrile. Depending on the selected substrates, the reaction was performed in TFE under reflux or under microwave irradiation. Only for the two examples, a transition metal catalyst was used.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 38487-86-4. Name: 2-Amino-4-chlorobenzonitrile.