In an article, author is Wu, Pingjie, once mentioned the application of 103146-25-4, Safety of 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile, Name is 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile, molecular formula is C20H23FN2O2, molecular weight is 342.4072, MDL number is MFCD06795501, category is nitriles-buliding-blocks. Now introduce a scientific discovery about this category.
Copper-Catalyzed Three-Component Reactions of 2-Iodo-2,2-difluoroacetophenones, Alkynes, and Trimethylsilyl Cyanide
A Cu(I)-catalyzed three-component reaction of 2-iodo-2,2-difluoroacetophenones, alkynes, and TMSCN is described. The reaction provided a facile method for the synthesis of difluoroacyl-substituted nitriles, which might be served as potentially useful fluoroorganic intermediates for further transformation in drug discovery. This method has broad substrate scope, good efficiency, and excellent stereoselectivity. Preliminary mechanistic investigation indicated that a radical-mediated process was involved in this cyanodifluoroalkylation reaction.
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