Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.622-75-3, Name is 2,2′-(1,4-Phenylene)diacetonitrile, SMILES is N#CCC1=CC=C(CC#N)C=C1, belongs to nitriles-buliding-blocks compound. In a document, author is Hinzmann, Alessa, introduce the new discover, SDS of cas: 622-75-3.
Chemoenzymatic Cascades toward Aliphatic Nitriles Starting from Biorenewable Feedstocks
A modern concept of producing nitriles involves aldoxime dehydratases, which are capable of dehydrating aldoximes to the corresponding nitriles without need of a cofactor. Aldoximes as the starting material for nitrile synthesis are easily prepared by condensation of hydroxylamine with the corresponding aldehydes. In this contribution we present chemoenzymatic cascade reactions toward nitriles consisting of an initial nitroxyl radical-catalyzed oxidation of aliphatic alcohols to aldehydes using sodium hypochlorite as the oxidation agent, subsequent condensation of the aldehyde with hydroxylamine, and a biocatalytic dehydration using aldoxime dehydratases to the corresponding nitriles without isolation of intermediates and using the product nitrile as a solvent. These formal solvent-free cascades open up the possibility to use biorenewable sources, namely fatty acids, as the starting material for a chemoenzymatic nitrile synthesis. We were also able to apply this cascade concept for the synthesis of aliphatic dinitriles, which are used as, e.g., a precursor for polymer building blocks. Overall yields without isolation of intermediates of up to 70% with very simple product isolation were achieved.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 622-75-3 is helpful to your research. SDS of cas: 622-75-3.