Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Name: 3-Chlorobenzonitrile, 766-84-7, Name is 3-Chlorobenzonitrile, molecular formula is C7H4ClN, belongs to nitriles-buliding-blocks compound. In a document, author is Nakao, Yoshiaki, introduce the new discover.
Metal-mediated C-CN Bond Activation in Organic Synthesis
Nitriles are ubiquitous versatile building blocks in organic synthesis. Common reactions of nitriles include the transformation of cyano groups into carbonyl and amine moieties. The functionalization of nitriles can also be accomplished at the alpha-position of alkanenitriles and at the ortho-position of cyanoarenes. On the other hand, the C-CN bond of nitriles has rarely been recognized as a valuable reaction site due to its thermodynamic robustness. Although it has been known for a long time in organometallic chemistry that C-CN bonds can be cleaved by transition-metal complexes, this elemental reaction had not been used in catalytic synthetic transformations of nitriles until two decades ago. This review surveys the progress of metal-catalyzed reactions of nitriles via C-CN bond activation. After introducing several different modes to activate C-CN bonds by various transition metals, catalytic reactions are categorized mainly into two parts: (i) reactions with CN as a leaving group and (ii) reactions with nitriles as a source of CN groups. Cross-coupling-type transformations with a cyano leaving group, cyanation reactions using nitriles as a nontoxic cyano source, and novel synthetic reactions such as carbocyanation are highlighted together with useful demonstrations of their utility in organic synthesis.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 766-84-7. Name: 3-Chlorobenzonitrile.