Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 123-06-8, Name is Ethoxymethylenemalononitrile, molecular formula is , belongs to nitriles-buliding-blocks compound. In a document, author is Panda, Surajit, HPLC of Formula: C6H6N2O.
Efficient alpha-Alkylation of Arylacetonitriles with Secondary Alcohols Catalyzed by a Phosphine-Free Air-Stable Iridium(III) Complex
A well-defined and readily available air-stable dimeric iridium(III) complex catalyzed alpha-alkylation of arylacetonitriles using secondary alcohols with the liberation of water as the only byproduct is reported. The alpha-alkylations were efficiently performed at 120 degrees C under solvent-free conditions with very low (0.1-0.01 mol %) catalyst loading. Various secondary alcohols including cyclic and acyclic alcohols and a wide variety of arylacetonitriles bearing different functional groups were converted into the corresponding alpha-alkylated products in good yields. Mechanistic study revealed that the reaction proceeds via alcohol activation by metal-ligand cooperation with the formation of reactive iridium-hydride species.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 123-06-8, in my other articles. HPLC of Formula: C6H6N2O.