Chemistry is an experimental science, COA of Formula: C8H11N, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 591769-05-0, Name is 3-Cyclopentylacrylonitrile, molecular formula is C8H11N, belongs to nitriles-buliding-blocks compound. In a document, author is Dotzauer, Simon.
A CO2-Mediated Conjugate Cyanide Addition to Chalcones
Carbon dioxide is an intrinsically stable molecule; however, it can readily react with various nucleophilic reagents. In the presence of a cyanide source, CO2 was proven to be useful to promote addition reactions. Here we report the use of CO2 to facilitate 1,4-conjugate cyanide addition reaction to chalcones to generate organonitriles. Nitriles are key component in organic synthesis due to their utility in numerous functional group transformation, however, conjugation addition of cyanide has been a challenge in this substrate class due to side reactions. To mitigate this, we employed simple ammonium and metal cyanide sources as nucleophiles under carbon dioxide atmosphere where high selectivity toward the desired product was obtained. The presented reaction is not feasible under inert atmosphere, which highlights the important role of CO2, as a Lewis and Brondsted acidic catalyst. Further derivatization of organonitriles compounds were performed to showcase the utility of the reaction, while an unprecedented dimerization reaction was identified and characterized, affording a cyclopentanone scaffold.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 591769-05-0. COA of Formula: C8H11N.