A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 22445-42-7, Name is 3,5-Dimethylbenzonitrile, molecular formula is C9H9N. In an article, author is Reddy, Potuganti Gal,once mentioned of 22445-42-7, SDS of cas: 22445-42-7.
CuI/I-2-Catalyzed Concise Synthesis of Substituted 6-Aminoisoquinolinoquinazoline Carboxylates from Anthranilamide
A one pot sequential addition protocol for synthesis of polycyclic quinazolines with beta-amino acid motifs has been achieved starting from anthranilamide. Initialin situformation of 2-(2-bromophenyl)quinazolin-4(3H)-one followed by addition of alkyl cyanoacetates catalyzed by copper (I) salts gives the target compound in good to excellent yields. The expedient and facile cascade protocol involves nucleophilic alpha-arylation, intramolecular cycloamidation of nitriles followed by 1,3-hydrogen shift allowing direct access to 6-amino-8-oxo-8H-isoquinolino[1,2-b]quinazoline-5-carboxylates.
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