766-84-7, Name is 3-Chlorobenzonitrile, molecular formula is C7H4ClN, Application In Synthesis of 3-Chlorobenzonitrile, belongs to nitriles-buliding-blocks compound, is a common compound. In a patnet, author is Chen, Ying, once mentioned the new application about 766-84-7.
Assembly of alpha-(Hetero)aryl Nitriles via Copper-Catalyzed Coupling Reactions with (Hetero)aryl Chlorides and Bromides
alpha-(Hetero)aryl nitriles are important structural motifs for pharmaceutical design. The known methods for direct synthesis of these compounds via coupling with (hetero)aryl halides suffer from narrow reaction scope. Herein, we report that the combination of copper salts and oxalic diamides enables the coupling of a variety of (hetero)aryl halides (Cl, Br) and ethyl cyanoacetate under mild conditions, affording alpha-(hetero)arylacetonitriles via one-pot decarboxylation. Additionally, the CuBr/oxalic diamide catalyzed coupling of (hetero)aryl bromides with alpha-alkyl-substituted ethyl cyanoacetates proceeds smoothly at 60 degrees C, leading to the formation of alpha-alkyl (hetero)arylacetonitriles after decarboxylation. The method features a general substrate scope and is compatible with various functionalities and heteroaryls.
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