In an article, author is Zhang, Chunyan, once mentioned the application of 623-03-0, Safety of 4-Chlorobenzonitrile, Name is 4-Chlorobenzonitrile, molecular formula is C7H4ClN, molecular weight is 137.57, MDL number is MFCD00001813, category is nitriles-buliding-blocks. Now introduce a scientific discovery about this category.
A practical base mediated synthesis of 1,2,4-triazoles enabled by a deamination annulation strategy
A rapid and efficient base mediated synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed using the annulation of nitriles with hydrazines, which can be expanded to a wide range of triazoles in good to excellent yields. Ammonia gas is liberated during the reaction, and halo and hetero functional groups as well as free hydroxyl and amino groups are tolerated in this transformation. A variety of alkyl and aryl-substituted nitriles can be functionalized with aromatic and aliphatic hydrazines employing this procedure. This finding provides a practical and useful strategy for the synthesis of various N-15-labeled 1,2,4-triazole derivatives, and two types of mGlu5 receptor pharmaceuticals can be easily assembled in a one-pot manner.
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