Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Dai, Ling, once mentioned the application of 19472-74-3, Name is 2-Bromophenylacetonitrile, molecular formula is C8H6BrN, molecular weight is 196.0439, MDL number is MFCD00001896, category is nitriles-buliding-blocks. Now introduce a scientific discovery about this category, Category: nitriles-buliding-blocks.
Palladium-catalyzed C-H activation of simple arenes and cascade reaction with nitriles: access to 2,4,5-trisubstituted oxazoles
An efficient and straightforward protocol for the assembly of the pharmaceutically and biologically valuable oxazole skeleton is achieved for the first time from readily available simple arenes and functionalized aliphatic nitriles. This transformation involves palladium-catalyzed C-H activation, carbopalladation and a tandem annulation sequence in one pot. Notably, the reaction proceeds efficiently under redox-neutral conditions, and exhibits high atom-economy. Deuterium-labeling experiments suggested that C-H bond cleavage of the simple arenes might be the rate-determining step.
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