Application of 57381-51-8,Some common heterocyclic compound, 57381-51-8, name is 4-Chloro-2-fluorobenzonitrile, molecular formula is C7H3ClFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 13: 1-(4-chloro-2-(piperidin-1-yl)benzyl)-3-(2,3-dihydro-2-oxo-1H-benzo[d]imidazol-4-yl)urea Preparation of 4-chloro-2-(piperidin-1-yl)benzonitrile 16ah (scheme 8) To commercially available 2-fluoro-4-chlorobenzonitrile (2.2 g, 12.87 mmol) piperidine (4equiv., 5.6 ml) was added and the solution was heated at 80C overnight. The reaction was evaporated and to the residue water was added and the solid material was filtrated, washed with water and dried obtaining 3 g of a pale yellow solid. Yield = 97% 1HNMR (DMSO, 200 MHz) delta 1.54 (2H, m), 1.65 (4H, m), 3.14 (4H, m), 7.09 (1H, dd, J = 8.2 Hz, J’ = 2 Hz), 7.14 (1H, m), 7.69 (1H, d, J = 8.4 Hz)
The synthetic route of 57381-51-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Pharmeste S.r.l.; EP2377850; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts