Related Products of 13544-06-4,Some common heterocyclic compound, 13544-06-4, name is 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile, molecular formula is C9H5F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1.75 g (7.6 mmol) (2-Nitro-4-trifluoromethylphenyl)-acetonitrile in 20 ml THF are cooled to 0C in a nitrogen atmosphere and treated with 60 mi BH3/THF- complex (1 M in THF). The reaction mixture is allowed to slowly warm up to room temperature overnight. After 72 h the reaction solution is slowly given to 50 ml 5 N HO gegeben and then 1 h heated to reflux. The reaction mixture is evaporated to dryness, the residue made alkaline (pH 12-14) with 25% NaOH solution and extracted 2x with 100 mi ethylacetate. The combined organic phases are washed with brine, dried using Na2SO4, filtered and evaporated. Yield : 1.8 g (77 %) 112, brown oil
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile, its application will become more common.
Reference:
Patent; MERCK PATENT GMBH; WO2005/75425; (2005); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts