Adding a certain compound to certain chemical reactions, such as: 53312-77-9, name is 2-Amino-3-chlorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 53312-77-9, Product Details of 53312-77-9
BH3THF complex (1M in THF, 26 mL, 26.2 mmol) was added ina dropwise manner at 0 C (ice-bath) to 2-amino-3-chlorobenzonitrile (7) (1.00 g, 6.6 mmol) under an N2 atmosphere.The stirred reaction mixture was heated at reflux overnight,allowed to cool to room temperature, quenched by addition of HCl(6 N, to pH 2), and heated at reflux for 30 min. The reaction mixturewas allowed to cool to room temperature and then cooled to 0 C(ice-bath) and basified with NaOH (3 M, to pH 12) and extractedwith CH2Cl2 (2 40 mL). The combined organic portion waswashed with H2O (100 mL), dried (MgSO4) and evaporated underreduced pressure to afford 0.93 g (90%) of 8 as a sticky solid. IRspectroscopy indicated the absence of a characteristic cyano band
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Reference:
Article; Abdelkhalek, Ahmed S.; Musayev, Faik N.; Iyer, Kavita A.; Hemanth, Prithvi; Safo, Martin K.; Dukat, Ma?gorzata; Journal of Molecular Structure; vol. 1202; (2020);,
Nitrile – Wikipedia,
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