In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 628-20-6 as follows. category: nitriles-buliding-blocks
4-chloro-nitrile (103.5mg, 1.0mmol, 5.0equiv. ) And Na 2 S 2 O 3 ¡¤ 5H 2 O (248.2mg, 1.0mmol, 5.0equiv. After) was added to the reaction tube, followed by addition of the reaction solvent of ethanol / water (0.25mL / 0.5mL), and stirred at a reaction temperature of 100 C for 2 hours. Then the reaction system was cooled, the solvent was removed under reduced pressure, followed by addition of Sodium trifluoromethylbenzene (46.5mg, 0.2mmol, 1.0equiv.), Then added to the reaction solvent, 1,4-dioxane ring (1.0mL), and stirred at a reaction temperature of 110 C for 11 hours. The reaction solution was cooled to room temperature. Methylbenzoate was then added triphenylphosphine (36.5mg, 0.12mmol, 0.6equiv.), Stirred at room temperature for 4 hours, the reaction solution under reduced pressure and finally the solvent removed to give product 20 after column chromatography (elution agent polarity: stone ether / ethyl acetate 40:1). Yield: 62%
According to the analysis of related databases, 628-20-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; East China Normal University; JIANG, XUEFENG; XIAO, XIAO; FENG, MINGHAO; (30 pag.)CN104387303; (2016); B;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts