Electric Literature of 53312-79-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 53312-79-1, name is 3-Amino-4-chlorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.
Under nitrogen protection, a water separator was installed in a 2L four-necked flask, and 152.6 g of 2-chloro-5-cyanoaniline, 130 g of benzaldehyde, 12 g of p-toluenesulfonic acid and 1.2 L of xylene were added, and the mixture was refluxed for 6 hours.The reaction can be stopped without significant water droplets in the water separator.After cooling to room temperature, it was washed with 100 mL of 10% aqueous sodium hydroxide solution, and the organic phase was decomposed under reduced pressure.The obtained residue was distilled under reduced pressure to give 215 g of the desired product N-benzylidene-2-chloro-5-cyanoaniline. The gas chromatographic content was 98.4%, and the yield was 89.3%.
The chemical industry reduces the impact on the environment during synthesis 3-Amino-4-chlorobenzonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Shanghai Kangpeng Technology Co., Ltd.; Zeng Yuan; Zhou Yan; Li Bolan; Chen Xiaobin; Wang Daoxiang; Yang Jianhua; (19 pag.)CN108276294; (2018); A;,
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