Synthetic Route of 193290-27-6, These common heterocyclic compound, 193290-27-6, name is 3-(2-Hydroxyethyl)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a cooled (0 C) solution of S154 (150 mg, 1.019 mmol) in CH2Cl2 (8 mL) were added MsCl (0.16 mL, 2.038 mmol) and Et3N (0.43 mL, 3.057 mmol). After stirring for 0.5 h at 0 C, brine was added. The layers were separated and the aqueous layer was extracted with CH2Cl2. The combined organic layers were dried over anhydrous Na2SO4 and concentrated in vacuo. To a cooled (0 C) solution of the crude mixture in THF/DMF (4/1, 15 mL) were added TrtSH (1.13 g, 4.076 mmol) and NaH (60% dispersion in mineral oil, 163 mg, 4.076 mmol). After stirring for 16 h at 25 C, the reaction mixture was quenched by the addition of saturated NH4Cl solution and diluted with EtOAc. The layers were separated and the aqueous layer was extracted with EtOAc. The combined organic layers were dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by column chromatography (silica gel, EtOAc/hexanes = 1/30) to afford S16 (1.8 g, 94% for two steps)
Statistics shows that 3-(2-Hydroxyethyl)benzonitrile is playing an increasingly important role. we look forward to future research findings about 193290-27-6.
Reference:
Article; Kim, Bumki; Park, Heekwang; Salvador, Lilibeth A.; Serrano, Patrick E.; Kwan, Jason C.; Zeller, Sabrina L.; Chen, Qi-Yin; Ryu, Soyoung; Liu, Yanxia; Byeon, Seongrim; Luesch, Hendrik; Hong, Jiyong; Bioorganic and Medicinal Chemistry Letters; vol. 24; 16; (2014); p. 3728 – 3731;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts