In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 950596-58-4 as follows. SDS of cas: 950596-58-4
Example 3: Preparation of Erlotinib Trifluoro acetate2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile (25 g) was charged into ethanol (350 ml) at 25C to 300C and stirred for 10 minutes to 15 minutes to get a clear solution. 3-ethynyl aniline (11.1 g) followed triethyl orthoformate (20.86g) was charged into reaction mass at 25C to 300C. Trifluoroacetic acid (3.8ml) was added slowly drop-wise into the reaction mixture at 250C to 300C and stirred for 30 minutes at 25C to 300C. Trifluoroacetic acid (3.8ml) was added slowly drop wise to reaction mixture at 250C to 300C and stirred for 30 minutes at 25C to 300C. Again, trifluoroacetic acid (3.8ml) was added slowly drop wise to reaction mixture at 250C to 300C and stirred for 30 minutes at 250C to 300C. The reaction mixture was refluxed for about 24 hours at 750C to 800C and Cooled to 25C to 300C. Ethanol (-150 ml) was recovered from the reaction mixture under vacuum at 55C to 600C. The solution obtained was Cooled to 25C to 300C and stirred for about 18 hours at 25C to 300C. The solid obtained was filtered, washed with ethanol (2x25ml) and dried under vacuum for about 18 hours at 400C to 450C to give erlotinib trifluoroacetate.Yield: 29.2 g. Purity: 97.35%
According to the analysis of related databases, 950596-58-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; RANBAXY LABORATORIES LIMITED; MURUGESAN, Balaguru; VEMPALI, Anandam; SATHYANARAYANA, Swargam; THAPER, Rajesh, Kumar; PRASAD, Mohan; WO2010/109443; (2010); A1;,
Nitrile – Wikipedia,
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