In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 63069-50-1 as follows. category: nitriles-buliding-blocks
To a solution of reagent 1 (13 g, 0.096 mol) in 200 mL of CH2CI2 was added ICI (20 g, 0.12 mol) at room temperature. The mixture was stirred at room temperature overnight. The mix- ture was evaporated to dryness. Flash chromatography (silica, petroleum ether: EtOAc 50:1 ) gave reagent 2 (13.6 g, 54%). 1H NMR (CDCI3) delta 7.72 (t, 1 H), 7.24-7.27 (m, 1 H), 4.70 (br s, 2 H).
According to the analysis of related databases, 63069-50-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; H. LUNDBECK A/S; ESKILDSEN, J¡ãrgen; WO2014/49133; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts