Synthetic Route of 57381-37-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 57381-37-0, name is 2-Bromo-5-chlorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Under the protection of nitrogen,To 2-(3-((6-fluoroquinolin-4-yl)oxy)-8-azabicyclo[3.2.1]oct-8-yl)propanamide (100 mg, 0.3 mmol),2-bromo-5-chlorobenzonitrile (63 mg, 0.3 mmol) and NaOH (14 mg, 0.3 mmol) in 2 mL of NMPCuI (6 mg, 0.03 mmol) was added to the solution.The reaction mixture was stirred at 120 C overnight.The reaction system was poured into 10 mL of water.Extract with EA (10 mL x 3).The organic phase is washed with saturated brine.Dry anhydrous Na2SO4 and concentrate under reduced pressure.The residue was chromatographed on silica gel (DCM:MeOH = 10:1)Purification afforded 30 mg (yield: 21%) of the title compound.It is a white solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-5-chlorobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Chengdu Hai Borui Pharmaceutical Co., Ltd.; Chengdu Beite Pharmaceutical Co., Ltd.; Huang Haoxi; Liu Guanfeng; Ren Junfeng; Yi Shoubing; Chen Tonghun; He Quanhong; Wu Xiancai; Li Yingfu; Su Zhonghai; (91 pag.)CN109575022; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts