Application of 7357-70-2,Some common heterocyclic compound, 7357-70-2, name is 2-Cyanothioacetamide, molecular formula is C3H4N2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation 8 Synthesis of 2-cyano-3-oxo-thiobutyramide To a stirring solution of 2-cyano-thioacetamide, (1016 g, 9.84 mol) in pyridine (2.60 L), chilled to 0 C., add acetyl chloride over 2 hours (785 mL, 11.03 mol) keeping reaction temperature below 20 C. Warm to room temperature over 1 hour, add water (4 L) and stir until dissolution of all solids. Add an aqueous 12 M solution of hydrochloric acid (HCl, 250 mL) until acidic (pH=1) to give a red-brown precipitate. Stir for 1 hour at 0 C., filter, dry the collected solid under vacuum to give the title compound as an orange solid (926 g, 66%). A second crop can be harvested from the mother liquors by adding 12 M aqueous (500 mL) to give the title compound (353 g, 25%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Cyanothioacetamide, its application will become more common.
Reference:
Patent; Britton, Thomas Charles; Dehlinger, Veronique; Fivush, Adam Michael; Hollinshead, Sean Patrick; Vokits, Benjamin Paul; US2009/253750; (2009); A1;,
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