Synthetic Route of 6621-59-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6621-59-6, name is 6-Bromohexanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: K2CO3, KOH and TBAB were added to a solution of each triazole compound (7a-c) in ACN. Each solution was stirred for 30 min at room temperature; alkyl bromide was added, and the reaction proceeded for 3-24 h at room temperature. The solid was filtered and then washed with diethyl ether. The solvent of the filtrate was removed in vacuo and purified by silica gel column chromatography (hexane/ethyl acetate) to yield the desired compound or crude mixture, which were reacted in the next step of deprotection.
The synthetic route of 6-Bromohexanenitrile has been constantly updated, and we look forward to future research findings.
Reference:
Article; Lee, Sun-Mi; Yoon, Kyoung Bin; Lee, Hyo Jeong; Kim, Jiwon; Chung, You Kyoung; Cho, Won-Jea; Mukai, Chisato; Choi, Sun; Kang, Keon Wook; Han, Sun-Young; Ko, Hyojin; Kim, Yong-Chul; Bioorganic and Medicinal Chemistry; vol. 24; 21; (2016); p. 5036 – 5046;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts