Application of 19924-43-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19924-43-7, name is 2-(3-Methoxyphenyl)acetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: To a stirring suspension of KOtBu (2.0 mmol) in 1,4-dioxane (5 mL) at 0C, corresponding (het)arylacetonitrile (1a-f, 10a-c) (1.0 mmol) in 1,4-dioxane (2 mL) was added dropwise. After further stirring for 10 minutes, a solution of respective Dithioester (2a-i) (1.0 mmol) in 1,4-dioxane (2 mL) was added to the reaction mixture at 0C, followed by further stirring for 1 h at ambient temperature (monitored by TLC). Iodine (506 mg, 2.0 mmol) was added and the reaction mixture was heated at 90C with continuous stirring (monitored by TLC). It was then diluted with 10% aq. Na2S2O3 solution (50 mL) and extracted with EtOAc (3×25 mL), and the combined organic layer was washed with water (3×25 mL) and brine (1×25 mL), dried (anhyd. Na2SO4), and concentrated under reduced pressure. The crude products were purified by silica gel column chromatography using EtOAc/hexane as eluent.
The synthetic route of 2-(3-Methoxyphenyl)acetonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Article; Bonagiri, Saraiah; Acharya, Anand; Pasha, Mohamed A.; Hiriyakkanavar, Ila; Tetrahedron Letters; vol. 58; 49; (2017); p. 4577 – 4582;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts