The synthetic route of 127946-77-4 has been constantly updated, and we look forward to future research findings.
Electric Literature of 127946-77-4, These common heterocyclic compound, 127946-77-4, name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 5To a solution of 3-(morpholin-4-sulfonyl)-2(i?)-[2,2,2-trifluoro-l(5}-(4-fluorophenyl)- EPO ethylamino] -propionic acid (0.034 g, 0.082 mmol) and the HCl salt of 1-aminocyclopropane- carbonitrile (OmegaChem, 0.013 g, 0.107 mmol) in DMF (1 mL) at rt was added solid HATU (PacificChem, 0.041 g, 0.107 mmol) in one portion followed by DIPEA (Aldrich, 0.043 mL, 0.246 mmol) to produce a bright yellow, clear solution. After stirring at rt for 1 h, the reaction was diluted in EtOAc and quenched with 10% aqueous NaHCO3. Water was added to dissolve precipitated solids. The aqueous layer was separated and extracted with EtOAc. The combined organics were washed with brine and dried over anhydrous Na2SO4. Following concentration in vacuo, the crude product was purified by column chromatography on SiO2 (2/1 EtOAc/Hex). Following concentration in vacuo, 0.020 g (51%) of N-(l-cyanocyclopropyl)-3-(morpholin-4- sulfonyl)-2(R)-[2,2,2-trifluoro- 1 (5)-(4-fluorophenyl)ethylamino]propionamide was obtained as?a white foamy solid with repeated concentration from CH2Cl2. LC/MS: 501.4 (M+Nua)+; 479.3 (M+H)+; 477.2 (M-H)”.
The synthetic route of 127946-77-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AXYS PHARMACEUTICALS, INC.; WO2006/60810; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts