Introduction of a new synthetic route about 115661-37-5

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Adding a certain compound to certain chemical reactions, such as: 115661-37-5, name is 2-Amino-3-fluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 115661-37-5, Recommanded Product: 2-Amino-3-fluorobenzonitrile

2-(1-cyclopropyl-5-oxo-2,5-dihydro-1H-pyrrol-3-ylamino)-3-fluorobenzonitrile2-Amino-3-fluorobenzonitrile (1.1 g, 8.08 mmol) and 1-cyclopropyl-4-methoxy-1H-pyrrol-2(5H)-one (1.170 g, 7.64 mmol) were combined in acetic acid (10 mL) and heated to 80 C. Methanesulfonic acid (1.311 mL, 20.20 mmol) was dissolved in acetic acid (2 mL) and added dropwise via syringe over 15 minutes. The reaction was stirred for 1 hour at 80 C. and then cooled to RT and placed on a rotoevaporator under high vacuum for 15 minutes at 55 C. to remove the acetic acid. The resulting oil was dissolved in methylene chloride (80 mL) and slowly added dropwise over 20 minutes to a solution of saturated aqueous sodium bicarbonate (70 mL) mixed with 5 N sodium hydroxide (20 mL). This resultant biphasic system was separated. The aqueous was extracted 2 more times with methylene chloride (60 ml) and all organics were combined, dried over magnesium sulfate, and filtered. The filtrate was evacuated to produce 1.5 grams of tan solid. This solid was dissolved in methylene chloride and methanol. Silica gel was added (10 g) and solvent removed. The residue was purified via flash column eluting with ethyl acetate/methylene chloride to afford 2-(1-cyclopropyl-5-oxo-2,5-dihydro-1H-pyrrol-3-ylamino)-3-fluorobenzonitrile as an off white solid (87%). 1H NMR (500.333 MHz, DMSO) delta 9.18 (s, 1H), 7.70 (m,1H), 7.45 (m, 1H), 4.49 (s, 1H), 3.99 (s, 2H), 2.57 (m, 1H), 0.65 (m, 4H). MS APCI, m/z=258 (M+H). HPLC 1.66 min.

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Reference:
Patent; ASTRAZENECA AB; US2008/318943; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts