Adding a certain compound to certain chemical reactions, such as: 368-77-4, name is 3-(Trifluoromethyl)benzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 368-77-4, Product Details of 368-77-4
A suspension of 3-(trifluoromethyl)benzonitrile (16c) (2.35 mL, 17.53 mmol, 1.00 equiv), hydroxylamine hydrochloride (1.58 g, 22.79 mmol, 1.30 equiv) and sodium carbonate (2.42 g, 22.79 mmol, 1.30 equiv) in ethanol (abs, 20 mL) was heated to reflux for 22 h. After 3 h, further hydroxylamine hydrochloride (1.30 equiv) and sodium carbonate (1.30 equiv) were added. The inorganic solids were removed by filtration and the solvent was removed in vacuum to give 3.60 g of a colorless oil that solidifies over time (quant.). 26 1H NMR (250 MHz, CDCl3): delta = 7.90 (s, 1H, 2H-ph-CF3), 7.82 (d, 1H, 3J = 7.8 Hz, 4H-ph-CF3), 7.68 (d, 1H, 3J = 7.8 Hz, 6H-ph-CF3), 7.53 (t, 1H, 3J = 7.8 Hz, 5H-ph-CF3), 4.92 (br s, 2H, NH2), 1.89 (s, 1H, -OH); ESI-MS: m/z = 204.6 [M+H]+.
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Reference:
Article; Flesch, Daniel; Gabler, Matthias; Lill, Andreas; Gomez, Roberto Carrasco; Steri, Ramona; Schneider, Gisbert; Stark, Holger; Schubert-Zsilavecz, Manfred; Merk, Daniel; Bioorganic and Medicinal Chemistry; vol. 23; 13; (2015); p. 3490 – 3498;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts