Adding a certain compound to certain chemical reactions, such as: 6011-14-9, name is 2-Aminoacetonitrile hydrochloride, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6011-14-9, name: 2-Aminoacetonitrile hydrochloride
The coupling of an aminonitrile to a carboxylic acid and subsequentBoc-deprotection is described and is referred to as General Method 6. To a solution ofCompound 101-N (180 mg, 0.15 mmol), aminoacetonitrile hydrochloride (31 mg, 0.33 mmol) and DIPEA (38 mg, 0.29 mmol) in DCM/DMF (3 mL, 2:1) at 0C, HATU (56 mg, 0.15 mmol) was added while stirring. The resulting mixture was stirred at room temperature for lh. Most DCM was removed under reduced pressure and the residue was poured into water (10 mL),which was extracted with EtOAc (20 mL x 3). The combined organic layers were washed with brine (50 mL), dried over Na2504, concentrated to the residue, which was purified by flash chromatography column to afford Compound 101-0 (140 mg, 76%) as a white solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Aminoacetonitrile hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; RQX PHARMACEUTICALS, INC.; GENENTECH, INC.; CHEN, Yongsheng; SMITH, Peter Andrew; ROBERTS, Tucker Curran; HIGUCHI, Robert I.; PARASELLI, Prasuna; KOEHLER, Michael F. T.; SCHWARZ, Jacob Bradley; CRAWFORD, James John; LY, Cuong Q.; HANAN, Emily J.; HU, Huiyong; YU, Zhiyong; (424 pag.)WO2017/84630; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts