Reference of 57381-49-4, A common heterocyclic compound, 57381-49-4, name is 2-Bromo-4-chlorobenzonitrile, molecular formula is C7H3BrClN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[1,1′-bis(diphenylphosphino)dicene. Iron] Palladium dichloride (192.8 mg, 0.26 mmol) and potassium carbonate (1.09 g,7.91mmol) wereadded. The reaction mixture was heated to 110C and the reaction was stirred for 16 hours.The reaction solution was allowed to cool to room temperature and20 mL of water was addedto the reaction mixture. The mixture was extracted with ethyl acetate (20 mL ¡Á 3). The organic phases were combined and the organic phase was washed with saturated sodium chloride solution (20 mL ¡Á2) and dried over anhydrous sodium sulfate. The desiccant was removed by filtration, and the filtrate was concentrated under reduced pressure.The resulting residue was purifiedby silica gel column chromatography using an eluent system C togive the crude title product 4d (450 mg, yellow viscous product), which was directly introduced into the next reaction.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Jiangsu Hengrui Pharmaceutical Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.; Yang Fanglong; Chi Jiangtao; He Feng; Tao Weikang; (33 pag.)CN107793396; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts