Adding a certain compound to certain chemical reactions, such as: 60702-69-4, name is 2-Chloro-4-fluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 60702-69-4, Computed Properties of C7H3ClFN
To a cooled suspension of NaH (60% in mineral oil, 6.24 g, 156 mmol) in DMF (100 mL) at 5 C was added 3,5-dimethylpyrazole 30 (15.0 g, 156 mmol) dropwise. After stirring at 5 C for 30 min, 2-chloro-4-fluorobenzonitrile (24.3 g, 156 mmol) was added dropwise, and the whole was stirred at 0 C for 1 h. The mixture was diluted with water. The resulting precipitates were collected by filtration, washed with water and hexane, and dried in air. The resulting solid was purified by silica gel column chromatography (NH silica gel, hexane-EtOAc). The product was recrystallized from hexane-EtOAc to afford 31 (21.0 g, 58%) as a colorless powder. 1H NMR (300 MHz, CDCl3) delta: 2.29 (3H, s), 2.42 (3H, s), 6.07 (1H, s), 7.51 (1H, dd, J = 8.5 and 2.1 Hz), 7.70-7.76 (2H, m).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-4-fluorobenzonitrile, and friends who are interested can also refer to it.
Reference:
Article; Yamamoto, Satoshi; Tomita, Naoki; Suzuki, Yuri; Suzaki, Tomohiko; Kaku, Tomohiro; Hara, Takahito; Yamaoka, Masuo; Kanzaki, Naoyuki; Hasuoka, Atsushi; Baba, Atsuo; Ito, Mitsuhiro; Bioorganic and Medicinal Chemistry; vol. 20; 7; (2012); p. 2338 – 2352;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts