Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3672-47-7, name is 3-(4-Methoxyphenyl)-3-oxopropanenitrile, A new synthetic method of this compound is introduced below., Formula: C10H9NO2
General procedure: A mixture of 4-methoxybenzoylacetonitrile (1.75 g, 10.0 mmol), compound 2a (3.31 g, 11.2 mmol), Et3N (4.04 g, 40.0 mmol) in t-BuOH (120 mL) was stirred at RT for 22 h. The resulting precipitate was filtered, washed with solvent t-BuOH, dried in air, then washed with some water, and dried to give white solid product 3a (2.13 g). The filtrate was evaporated and residue was extracted with EtOAc (3 ¡Á 60 mL), washed with brine, dried over Na2SO4, and concentrated. The crude product was purified by column chromatography on silica gel with eluent (1:9 EtOAc/hexanes) to afford white solid compound 3a (0.49 g). Combined two parts of product gave 3a (2.62 g, 63%)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Gao, Mingzhang; Wang, Min; Zheng, Qi-Huang; Bioorganic and Medicinal Chemistry Letters; vol. 22; 11; (2012); p. 3704 – 3709;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts