Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 327056-73-5, name is 3-Chloro-5-fluorobenzonitrile, A new synthetic method of this compound is introduced below., Formula: C7H3ClFN
EXAMPLE 43 A mixture of sulfuric acid (500 ml) and water (100 ml) is heated to 95 and 3-chloro-5-fluorobenzonitrile (94.8 gms) added. After 4 hours the mixture is cooled and poured over ice and water added to make 3.6 L. In 1.2 L portions the mixture is filtered, the solid rinsed with hexane and the aqueous rinsed with hexane (4*120 ml) then extracted with ethyl acetate (2*100 ml). The solid and the ethyl acetate extracts were combined, dried over magnesium sulfate and stripped to give 3-chloro-5-fluorobenzamide as a white solid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Sandoz Ltd.; US5098466; (1992); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts