Application of 97165-77-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 97165-77-0 as follows.
To a flask was added 3,5-dibromobenzonitrile (3 g, 11.6 mmol), 4-(1-naphthyl)-benzenesulfonic acid (2.9 g, 11.6 mmol), potassium carbonate (4.1 g, 30 mmol)tetraphenyllphosphine palladium (0.1 g),tetrahydrofuran (30 mL) and water (15 mL)heated to reflux under nitrogen for 12 hours, cooled, extracted with dichloromethane, dried and concentrated. The crude product was purified by column chromatography to give 2.5 g of product in 57% yield.
According to the analysis of related databases, 97165-77-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shanghai Daoyi Chemical Technology Co., Ltd.; Huang Jinhai; Su Jianhua; (29 pag.)CN107033143; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts