Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4513-77-3, name is 2-Oxocyclohexanecarbonitrile, A new synthetic method of this compound is introduced below., Safety of 2-Oxocyclohexanecarbonitrile
To a solution of (2-methylphenyl) hydrazine hydrochloride (464 mg, 2.92 mmol) in ethanol (2 mL) was added 2-oxocyclohexanecarbonitrile (300 mg, 2.44 MMOL), and the mixture was heated to 60C and stirred for 16 h. The flask was then cooled to rt and the solvent was evaporated to give a solid. The crude residue of 2-(2-methylphenyl)-4, 5,6, 7- tetrahydro-2H-indazol-3-amine hydrochloride (449 mg, 70%) was used in the next step with no further purification. ES-MS m/z 228.2 (MH+) ; HPLC RT (min) 1.22.
The synthetic route of 4513-77-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2004/50650; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts