Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 332-25-2, name is 4-(Trifluoromethoxy)benzonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 4-(Trifluoromethoxy)benzonitrile
A solution of lithium aluminium hydride in diethyl ether (1.0M, 69.4 ml) was added dropwise to a stirred solution of 4-(trifluoromethoxy)benzonitrile (6.0 g) in diethyl ether (120 ml) over 15 minutes. Water (2.66 ml), 10percent sodium hydroxide solution (2.66 ml) and water (7.98 ml) were then added successively, dropwise. The precipitated solid was filtered off and washed with diethyl ether. The filtrate and washings were combined and evaporated under reduced pressure to give 4-(trifluoromethoxy)benzyl alcohol, N.M.R. in deuteriochloroform: delta2.3 (1H,s), 4.65 (2H,s), 7.2 (2H,d), 7.35 (2H,d).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Imperial Chemical Industries PLC; US5006543; (1991); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts