Some common heterocyclic compound, 151-18-8, name is 3-Aminopropanenitrile, molecular formula is C3H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 3-Aminopropanenitrile
A process for preparing 2-methyl-4-amino-5-aminomethylpyrimidine, comprising the steps of:1), 30 parts of DMF and 50 parts of dimethyl sulfate was added to a four-necked flask, the temperature was raised to 75 C, the reaction was stirred for 4 h, and then cooled to -10 C;2), slowly add 50 parts of sodium methoxide methanol solution, drip, and stir for 10 minutes;3) slowly adding 28 parts of 3-aminopropionitrile, stirring for 40 min, and distilling under reduced pressure to obtain intermediate 1;4), further adding 140 parts of dichloromethane and stirring for 20min, filtering, and the filtrate is subjected to distillation under reduced pressure to obtain intermediate 2;5), 75 parts of sodium methoxide methanol solution was added to a four-necked flask, cooled to -4 C, slowly added 40 parts of acetonitrile hydrochloride, stirred for 30 min, filtered, the filtrate was transferred to another flask and intermediate 2 was added. And 40 parts of sodium hydroxide, liter After warming to 25 C and stirring for 16 h, a solution of 2-methyl-4-amino-5-aminomethylpyrimidine was obtained, and the yield was 92.5%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 151-18-8, its application will become more common.
Reference:
Patent; Nanjing Jinhao Pharmaceutical Technology Co., Ltd.; Wu Jianzhong; Liu Weiqiang; Tong Hebing; Jiang Lihua; Wang Bucheng; (4 pag.)CN109293580; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts