Adding a certain compound to certain chemical reactions, such as: 193290-27-6, name is 3-(2-Hydroxyethyl)benzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 193290-27-6, Safety of 3-(2-Hydroxyethyl)benzonitrile
To a solution of 3-(2-hydroxy-ethyl)-benzonitrile (1 g; 6.79 mmol) in toluene (20 ml_), was added tetrabutylammonium hydrogen sulfate (230.70 mg; 0.68 mmol; 0.10 eq.) and NaOH (20 ml 5 M; 10 mmol) followed by the addition of tert-butyl bromoacetate (2 ml 13.59 mmol). Reaction mixture was stirred at RT under vigorous stirring for 9h. After this time, the aqueous phase was removed and the organic phase was diluted with EtOAc (50 ml_), washed with water (50 ml_) and brine (50 ml_). The combined organic layers were dried over magnesium sulfate, filtered and concentrated to give the title compound as a yellow powder (1.42 g; 80%). 1H NMR (DMSO-d6, 300 MHz) delta 7.74-7.73 (m, 1 H), 7.68-7.65 (m, 1 H), 7.63- 7.59 (m, 1 H), 7.51-7.46 (m, 1 H), 3.97 (s, 2H), 3.69 (t, J = 6.5 Hz, 2H), 2.88 (t, J = 6.5 Hz, 2H), 1.40 (s, 9H). LC/MS (Method B): 262.1 (M+H)+.
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Reference:
Patent; MERCK SERONO S.A.; WO2009/43889; (2009); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts