501-00-8, name is 2-(3-Fluorophenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 501-00-8
General procedure: General procedure for the reduction of nitrile by KBH4and CuCl2:To a 10 mL round-bottomed flask was added 2-(4-chlorophenyl)acetonitrile (0.1 5 g, 1 mmol), KBH4 (0.17 g, 3mmol), CuCl2 (0.03 g, 0.25 mmol) and 80 % isopropanol (1.6mL isopropanol and 0.4 mL water). The reaction completed in8 h at 60 C as evidenced by TLC (DCM:MeOH 10:1). Thereaction mixture was cooled to 25 C and removed the solvent.Ethyl acetate (5 mL) was added to the residue, washed withwater (1 mL) and brine (1 mL). The organic layer were dried withanhydrous Na2SO4, filtered and evaporated in vacuo to affordthe crude product.
The synthetic route of 501-00-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Jiang, Han; Hu, Jialei; Xu, Xinliang; Zhou, Yifeng; Asian Journal of Chemistry; vol. 27; 10; (2015); p. 3564 – 3566;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts