Synthetic Route of 72291-30-6,Some common heterocyclic compound, 72291-30-6, name is Methyl 2-cyano-2-methylpropanoate, molecular formula is C6H9NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 122-1 (2.0 g, 15.73 mmol, 1 eq), (Boc)20 (6.87 g, 31.46 mmol, 7.23 mL, 2 eq) and NiCl2 (203.9 mg, 1.57 mmol, 0.1 eq) in MeOH (40 mL) at 0C was added NaBH4 (4.17 g, 110.11 mmol, 7 eq) slowly portion-wise, and the resulting mixture was stirred at 20C for 16 h. The reaction mixture was quenched with NH4.H20 (10 mL), and then concentrated to remove solvent. And the residue was diluted with water (50 mL), and then extracted with EA (50 mL *3). The combined organic layers were washed with brine (50 mL), dried over anhydrous Na2S04, filtered and concentrated under reduced pressure to give a residue. The residue was purified by flash silica gel chromatography to give 122-2 (600 mg, 2.59 mmol, 16.5% yield). 1H NMR (400 MHz, CDCI3) d 4.97 (brs, 1H), 3.69 (s, 3H), 3.24 (d, J= 6.6 Hz, 2H), 1.44 (s, 9H), 1.19 (s, 6H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-cyano-2-methylpropanoate, its application will become more common.
Reference:
Patent; VIVACE THERAPEUTICS, INC.; KONRADI, Andrei W.; LIN, Tracy Tzu-Ling Tang; (559 pag.)WO2019/222431; (2019); A1;,
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