Adding a certain compound to certain chemical reactions, such as: 70484-01-4, name is 4-Bromophthalonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 70484-01-4, Quality Control of 4-Bromophthalonitrile
A stirrer,thermometer,condenser,A 100 mL four-necked glass flask equipped with a glass stopper was purged with nitrogen,The open end of the condenser was sealed with a gentle stream of nitrogen. Palladium acetate (1.1 mg, 0.005 mmol),2-dicyclohexylphosphino-2 ‘, 6’-dimethoxybiphenyl (4.1 mg, 0.01 mmol),4-bromophthalonitrile (104 mg, 0.5 mmol),4,4,5,5-tetramethyl-2- [p- (1,1,1,3,5,5,5-heptamethyltrisiloxane-3-yl) phenyl] -1,3- – borolane (255 mg, 0.6 mmol),And 1,4-dioxane (2 mL) were charged in a flask,The solid was dissolved by stirring at room temperature for 30 minutes. Cesium carbonate (326 mg, 1.0 mmol)Was added and the mixture was stirred at 25-29 C. for 12 days. Production of the target compound was confirmed by GC-MS of the reaction mixture.5 mL of toluene and 5 mL of water were added in order to the reaction mixture, and the mixture was stirred at room temperature for 5 minutes, then separated, and the organic layer was concentrated under reduced pressure.The residue was dissolved in toluene, filtered through 10 g of activated alumina, and the obtained crude product was purified by preparative GPC to obtain 142 mg of the objective compound as a white solid.
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Reference:
Patent; SHIN-ETSU CHEMICAL COMPANY LIMITED; KIYOMORI, AYUMU; ITOH, YUSUKE; (49 pag.)JP2015/10084; (2015); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts