Synthetic Route of 67832-11-5, These common heterocyclic compound, 67832-11-5, name is 4-Bromo-2-methylbenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 10; 3-(4-(5-(8-Bromo-6-(trifluor omethyl)imidazo [ 1 ,2-a] pyridin-2-yl)- 1 ,2,4-oxadiazol-3-yl)-3- methylphenyl) butanoic acid[00364] tert-Butyl 3-(4-cyano-3-methylphenyl) but-2-enoate (52).; To a stirred solution of 4-bromo-2-methylbenzonitrile (5.O g, 26 mmol) in dimethylacetamide (50 mL) was added tert-butyi crotonate (4.35 g, 30.6 mmol) and the reaction mixture was degassed with argon. To this solution, Pd(OAc)2 (0.114 g, 0.510 mmol) was added followed by tetraethylammonium chloride (4.22 g, 25.5 mmol) and the reaction was stirred at 1000C for 15 h. After completion, the reaction mixture was quenched with ice cold water and extracted with ether. The combined organic layers were washed with water, saturated NaCl solution, dried over Na2SO4 and concentrated in vacuo. The crude compound was purified by column chromatography to afford the title intermediate 52 as a yellow solid (5.2 g, yield 80%).
Statistics shows that 4-Bromo-2-methylbenzonitrile is playing an increasingly important role. we look forward to future research findings about 67832-11-5.
Reference:
Patent; EXELIXIS, INC.; CANNE BANNEN, Lynne; CHAN, Diva Sze-ming; GU, Xiao-hui; MAC, Morrison, B.; NG, Stephanie; WANG, Tie-lin; WANG, Yong; XU, Wei; WO2010/65760; (2010); A1;,
Nitrile – Wikipedia,
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