Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 499983-13-0, name is 4-Bromo-3-fluorophenylacetonitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 4-Bromo-3-fluorophenylacetonitrile
To a solution of compound A26-3 (9.6 g, 45 mmol) in THF (100 ml) under N2 at room temperature was added LDA (2M inTHF, 56 ml) over 1 h. Then the mixture was treated with iodomethane (22. 3g, 157.5 mmol). The mixture was then quenched by adding H20 (50 mL) and extracted with EtOAc (100 mL) three times. The combined organic layers were washed with brine, dried over Na2504, and concentrated in vacuo to provide a residue, which was purified by chromatography over silica gel (eluting with PE: EA=10: 1) to give compound A26-4.
According to the analysis of related databases, 499983-13-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; BIFU, Tesfaye; BIJU, Purakkattle; BLIZZARD, Timothy A.; CHEN, Zhengxia; CLEMENTS, Matthew J.; CUI, Mingxiang; FRIE, Jessica L.; HAGMANN, William K.; HU, Bin; JOSIEN, Hubert; NAIR, Anilkumar G.; PLUMMER, Christopher W.; WO2015/176267; (2015); A1;,
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