Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 939-80-0, name is 4-Chloro-3-nitrobenzonitrile, A new synthetic method of this compound is introduced below., Safety of 4-Chloro-3-nitrobenzonitrile
a. 3′-Amino-4′-chloro-benzonitrile A solution of 116 gm. of stannous chloride dihydrate in 280 ml. of concentrated hydrochloric acid is stirred and 25.2 gm. (0.14 mole) of 4′-chloro-3′-nitrobenzonitrile is added. The temperature rises to 81 and is allowed to cool to room temperature over a period of 2 hours. The mixture is cooled to 0 in an ice bath and 50% sodium hydroxide is added until strongly basic. The precipitate is removed by filtration. The precipitate is washed three times with ethyl acetate. The combined ethyl acetate extracts are shaken thoroughly with the aqueous filtrate. The phases are separated and the organic phase dried over magnesium sulfate. The drying agent is removed by filtration and the filtrate evaporated to dryness in vacuo. There is obtained 16.0 gm. of white crystalline solid that melts at 89-92.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; The Upjohn Company; US4091011; (1978); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts