52798-01-3, name is Methyl (4-cyanophenyl)acetate, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of Methyl (4-cyanophenyl)acetate
a) To a solution of methyl (4-cyanophenyl)acetate (4.00 g, 27.8 mmol) in MeOH (20 ml_), hydroxylamine hydrochloride (3.17 g, 45.7 mmol) and NaHCO3 (3.84 g, 45.7 mmol) is added. The suspension is stirred at 600C for 18 h before it is filtered and the filtrate is concentrated. The residue is dissolved in DCM, washed with water followed by brine, dried over MgSO4, filtered, concentrated and dried to give methyl [4-(N-hydroxycarbamimidoyl)- phenyl]-acetate (3.67 g) as a colourless oil; LC-MS: tR = 0.50 min, [M+1]+ = 209.05.
The synthetic route of 52798-01-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2008/29370; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts