Related Products of 69395-13-7, These common heterocyclic compound, 69395-13-7, name is 4-(2-Hydroxyethyl)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
a 1-(2-(4-Cyanophenyl)ethyl)methane sulphonate Methane sulphonyl chloride (0.856 g, 7.47 mmol) was added to a solution of 2-(4-cyanophenyl)ethanol (1.0 g, 6.80 mmol) and triethylamine (1.03 g, 10.18 mmol), in CH2 Cl2 (30 ml), at +5 C. The mixture was warmed to room temperature and stirred for 2 h before adding H2 O (15 ml), basifying with solid K2 CO3 and extracting with CH2 Cl2 (*3). The combined extracts were dried (Na2 SO4) and evaporated to afford the title-mesylate (1.52 g, 100%), delta (360 MHz, d6 -DMSO) 3.10 (2H, t, J=6.5Hz, CH2 -OMs), 3.12 (3H, s, OMs), 4.46 (2H, t, J=6.5Hz, CH2), 7.52 (2H, d, J=8.2Hz, Ar-H), 7.80 (2H, d, J=8.2Hz, Ar-H).
The synthetic route of 69395-13-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Merck Sharp & Dohme Ltd.; US5807857; (1998); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts