Electric Literature of 51762-67-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 51762-67-5 name is 3-Nitrophthalonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
With 3-hydroxybenzoic acid (15mmol) and 3-nitro-phthalonitrile (15mmol) as reactants, the solvent is anhydrous DMSO (30ml), potassium carbonate (45mmol) under nitrogen and the presence, stirred at room temperature The reaction 30 hours, by thin layer chromatography to monitor the end of reaction.The reaction mixture was diluted with sand core funnel filtration, the filtrate was collected, and the filtrate was added to 500ml of ice water mixture, adjusted with 1M hydrochloric acid solution until the solution was acidic precipitation heavy precipitate, was allowed to stand, an organic microporous membrane, repeated washing more times until the solution was neutral, the solid was collected and lyophilized to give a white solid, further use DMF- water purified by recrystallization to give a white desired product, a yield of about 78%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Nitrophthalonitrile, and friends who are interested can also refer to it.
Reference:
Patent; Fuzhou University; Huang, Bindong; Chen, Xingwei; Zheng, Qiaofeng; Ke, Meirong; (19 pag.)CN105622682; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts