Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 501-00-8, name is 2-(3-Fluorophenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 501-00-8
To a mixture of 5.8 mL (50 mmol) of 3- fluorophenylacetonitrile (5), 8.3 mL (100 mmol) of 1- bromo-2-chloroethane, and 0.23 g (1.0 mmol) of benzyltriethylammonium chloride was added 28 mL of 50% aqueous sodium hydroxide solution, and the resulting mixture was stirred at 40C for 3 hours [M. FEDORYNSKI and A. JONCZYK Org. Prep. Proc. Intl. (1995) 27,355- 3591. At this point 25 mL of ethylene glycol was added, and the mixture then was stirred at 100C for another 20 hours. After cooling to room temperature, the reaction mixture was diluted with water and then washed with ethyl acetate. The aqueous phase was adjusted to pH 2 employing hydrochloric acid and then extracted with diethyl ether. The combined extracts were washed with water and brine, dried over anhydrous sodium sulfate, filtered, and concentrated to provide 8.1 g of 1- (3- fluorophenyl) cyclopropane-l-carboxylic acid (6). NMR (300 MHz, DMSO-D6) 12.41 (br s, 1 H), 7.37-7. 29 (m, 1 H), 7.18-7. 03 (m, 3 H), 1.45 (d of d, 2 H), 1.17 (d of d, 2 H).
According to the analysis of related databases, 501-00-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2004/43911; (2004); A2;,
Nitrile – Wikipedia,
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